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DNA polymerase nu
is the most recently discovered DNA polymerase in the human genome. Pol nu is a family A polymerase meaning that it is either a replicative or repair polymerase. It is most closely related to Escherichia coli pol I, human POLQ, and Drosophila Mus308. Although the specific biological functions are unknown, it is known that Pol nu is related to DNA repair, translesion DNA synthesis, and homologous recombination. It is one of the types of polymerases that is conserved in vertebrates, but it is error-prone, meaning it has low base substitution fidelity. During the replication process in the nucleus, Pol nu discriminates poorly against the misinsertion of dNTP, specifically for guanine again thymine on the . Pol nu interacts with the DNA molecule at the of the finger domain on the protein.
