Amyloid fibrils were suspected for long to be the agents of Amyloid diseases,including Alzheimer’s,Parkinson’s and the prion conditions.But evidence suggests that smaller, often transient and polymorphic oligomers are the toxic entities.Segment of amyloid forming protein alpha-beta crystallin makes oligomeric complex which exhibits properties of other amyloid oligomers.The structure of oligomer shows a cylindrical barrel,made up of known as cylindrin.This segment(coloured in black) termed as forms the cylindrin structure.
PDB'S are
K11V (), K11V-Br2 (), K11V-Br8 (), K11VV2L (), K11V-TR (), and GDVIEV ().
Function
Disease
Relevance
Structural highlights
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