| Structural highlights
Function
[ENDSF_BACTN] Endosulfatase involved in the degradation of the glycosaminoglycans (GAGs) chondroitin sulfate (CS) and dermatan sulfate (DS). Efficiently hydrolyzes sulfate groups from a broad range of substrate size, including disaccharide to high molecular weight CS and DS polymers. Has a strict specificity for the 4-O-sulfate groups of galactosamine (PubMed:25002587). GAG-specific sulfatases play a key role in the persistence of the major human gut symbiont B.thetaiotaomicron in the host gastrointestinal tract (PubMed:25002587).[1] [2]
References
- ↑ Ulmer JE, Vilen EM, Namburi RB, Benjdia A, Beneteau J, Malleron A, Bonnaffe D, Driguez PA, Descroix K, Lassalle G, Le Narvor C, Sandstrom C, Spillmann D, Berteau O. Characterization of glycosaminoglycan (GAG) sulfatases from the human gut symbiont Bacteroides thetaiotaomicron reveals the first GAG-specific bacterial endosulfatase. J Biol Chem. 2014 Aug 29;289(35):24289-303. doi: 10.1074/jbc.M114.573303. Epub, 2014 Jul 7. PMID:25002587 doi:http://dx.doi.org/10.1074/jbc.M114.573303
- ↑ Ulmer JE, Vilen EM, Namburi RB, Benjdia A, Beneteau J, Malleron A, Bonnaffe D, Driguez PA, Descroix K, Lassalle G, Le Narvor C, Sandstrom C, Spillmann D, Berteau O. Characterization of glycosaminoglycan (GAG) sulfatases from the human gut symbiont Bacteroides thetaiotaomicron reveals the first GAG-specific bacterial endosulfatase. J Biol Chem. 2014 Aug 29;289(35):24289-303. doi: 10.1074/jbc.M114.573303. Epub, 2014 Jul 7. PMID:25002587 doi:http://dx.doi.org/10.1074/jbc.M114.573303
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