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=Human Gamma Secretase=

spinqualitylabelsall models Gamma Secretase 5A63 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Gamma Secretase 1.1 Introduction 1.1.1 practice 1.1.1.1 header 1.2 Function 1.3 Disease 1.4 Relevance 1.5 Structural highlights Gamma Secretase This is a default text for your page Layla Wisser/Sandbox 1. Click above on edit this page to modify. Be careful with the < and > signs. You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue. Introduction Figure 1 5A63 Article practice header Function [3] Disease [4] Relevance APP build up leads to Amyloid plaques in brain Inhibition of γ-secretase could be potential AD treatment Location of majority of mutations Over 200 mutations that cause AD AD mutations heavily target interface between PS1 and APP Important to look at differences between substrates Structural highlights example text [3] This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

References

1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
3. ↑ ^{3.0 3.1} Ransey E, Paredes E, Dey SK, Das SR, Heroux A, Macbeth MR. Crystal structure of the Entamoeba histolytica RNA lariat debranching enzyme EhDbr1 reveals a catalytic Zn(2+) /Mn(2+) heterobinucleation. FEBS Lett. 2017 Jul;591(13):2003-2010. doi: 10.1002/1873-3468.12677. Epub 2017, Jun 14. PMID:28504306 doi:http://dx.doi.org/10.1002/1873-3468.12677
4. ↑ Khan I, Krishnaswamy S, Sabale M, Groth D, Wijaya L, Morici M, Berger I, Schaffitzel C, Fraser PE, Martins RN, Verdile G. Efficient production of a mature and functional gamma secretase protease. Sci Rep. 2018 Aug 27;8(1):12834. doi: 10.1038/s41598-018-30788-w. PMID:30150752 doi:http://dx.doi.org/10.1038/s41598-018-30788-w

Student Contributors

Layla Wisser