Virus protease

Function

Virus protease or 3C protease or virus proteinase are virus cysteine proteases which have essential role in viral replication. The protease cleaves the precursor viral polyprotein to produce functional proteins and enzymes.^[1] F

Disease

Virus proteases are attractive target for therapeutic agents for treatment of diseases caused by the common cold virus. Coxsakievirus causes the human diseases myocarditis and pericarditis.

Structural highlights

Viral protease - a Cys protease fold is similar to that of trypsin-like serine proteases. The (PDB entry 1cqq).^[2] .

See also

• Immunodeficiency virus protease
  
• Human Immunodeficiency Virus
  
• HIV-1 protease
  
• HIV Protease Inhibitor Pharmacokinetics
  
• HIV Protease Inhibitor Resistance Profile
  
• HIV Protease Resistance
  
• Molecular Playground/Dengue Virus Protease
  
• Viability of a drug-resistant HIV-1 protease mutant
  
• Molecular Playground/Dengue Virus Protease
  
• FMDV 3C for Foot-and-Mouth virus protease
  
• SARS Coronavirus Main Proteinase
  

3D Structures of Virus proteases

Virus proteases 3D strutures