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Function of your protein
Inositol polyphosphate 1-Phosphatase (INPP1) is an enzyme that removes a phosphate group from a protein. Specifically, the phosphomonoester bond is removed from position 1 phosphate of Ins(1,4)P2 or Ins(1,3,4)P3. This protein also helps to regulate gluconeogenesis and nucleotide metabolism.
Biological relevance and broader implications
Important amino acids
These play an extensive role in interactions between 1-PO4 and 2-PO4 of the substrate to the active site. Also, there are a few different amino acids () that interact with the inositol ring and help reinforce the binding of the Ins(1,4)P2.
[3]
Structural highlights
,
Other important features
In the structure INPP1D54A, there is a mutation in the amino acid aspartic acid (D)54 and causes it to change to alanine (A)54 (). This mutation does not impact the substrate affinity but does decrease the activity of INPP1. [3]
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