Raptor (Rap) or Regulatory-Associated Protein of TOR 1 binds mTOR which controls cell growth, p70 S6 kinase α (S6K1) and the the initiation factor 4E binding protein 1 (4EBP1). The binding of Rap to mTOR is necessary for the mTOR-catayzed phosphorylation of the initiation factor binding protein
[1].
3D structures of raptor
Raptor 3D structures
Updated on 08-October-2023
6bcu - hRap + mTOR + target of rapamycin complex + Rheb + 4EBP1 peptide - human - Cryo EM
5h64 - hRap + mTOR + target of rapamycin complex - Cryo EM
6bcx - hRap + mTOR + target of rapamycin complex + 4EBP1 peptide - Cryo EM
5flc - hRap + mTOR + target of rapamycin complex + FKBP - Cryo EM
7owg, 7pea, 7peb, 7pec - hRap in mTOR complex - Cryo EM
6sb2 - hRap + mTOR + target of rapamycin complex + ras-related GTP-binding protein A,C - Cryo EM
6sb0 - hRap + mTOR + target of rapamycin complex + ras-related GTP-binding protein A,C + proline-rich AKT1 substate - Cryo EM
6sb0 - hRap + mTOR + ras-related GTP-binding protein A,C + regulator complex - Cryo EM
6u62 - hRap + mTOR + ras-related GTP-binding protein A,C + LAMTOR1-5 - Cryo EM
5wbi - AtRap - Arabidopsis thaliana
5wbj - AtRap + 4EBP1 peptide
5wbk - AtRap + S6K1 peptide
5wbl - AtRap + PRAS40 peptide
5ef5 - Rap - Chaetomium thermophilum
5fjl, 5fld - Rap fiber head domain - Siadenovirus A
References
- ↑ Chong ZZ, Shang YC, Maiese K. Cardiovascular disease and mTOR signaling. Trends Cardiovasc Med. 2011 Jul;21(5):151-5. doi: 10.1016/j.tcm.2012.04.005. PMID:22732551 doi:http://dx.doi.org/10.1016/j.tcm.2012.04.005
