Introduction
G protein-coupled receptors (GPCRs) are... [1]
GPCRs[2].
Image:7s8p.pdb
Structure overview
Active Site
Sub-pocket 1
Sub-pocket 2
Ligand interactions
Agonist
Antagonist
Mechanism Overview
Gi
Gq
Implications for disease and clinical relevance
medicinal drugs[3][4].
See Also
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References
- ↑ Cite error: Invalid
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- ↑ Millar RP, Newton CL. The year in G protein-coupled receptor research. Mol Endocrinol. 2010 Jan;24(1):261-74. Epub 2009 Dec 17. PMID:20019124 doi:10.1210/me.2009-0473
- ↑ Overington JP, Al-Lazikani B, Hopkins AL. How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. PMID:17139284 doi:10.1038/nrd2199
- ↑ Peeters MC, van Westen GJ, Li Q, IJzerman AP. Importance of the extracellular loops in G protein-coupled receptors for ligand recognition and receptor activation. Trends Pharmacol Sci. 2011 Jan;32(1):35-42. PMID:21075459 doi:10.1016/j.tips.2010.10.001
Student contributors
Madeline Beck
Joey Gareis
