G-Protein Coupled Receptors
G-protein coupled receptors(GCPRs) are a large family of cell surface membrane proteins. Once bound to a wide variety of extracellular ligands, GCPRs undergo a conformational change and relay information to intracellular secondary messengers [1]. This G protein activation results in a cellular response dependent on the ligand bound and location of the GPCR in the body. GCPRs can be broken down into five families: the rhodopsin family (class A, 701 members), the secretin family (class B, 15 members), the adhesion family (24 members), the glutamate family (class C, 15 members), and the frizzled/taste family (class F, 24 members) [2]. All of the families have a similar transmembrane (TM) domain consisting of seven ɑ-helices complexed with intracellular G proteins.
Class A GCPRs
MRGPRs
Structure with
Structure with
Types of Ligand Bound
Cation
Peptide
Specific Traits
Disulfide bonds
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PIF Motif
DRY Motif
Sodium Binding
MRGPRX2 Signaling Pathway
Function
Conformational Changes
What It Triggers
Clinical Relevance
Drugs
References
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