Function
Ras GTPase-activating protein-binding protein (G3BP) is a stress-granule protein that nucletes stress-granule assembly. Stress-granules are sites of mRNA storage that form by stress conditions like viral infection [1].
Disease
Relevance
Structural highlights
G3BP1 contains an N-terminal nuclear transfer factor 2 (NTF2-like) domain, RNA recognition motif domain and Arg-Gly-rich region[2]. The 3D structure of the complex between G3BP1 and Semliki forest virus peptide shows protein:peptide ratio of 2:1. The viral peptide sequence FGDF which appears twice interacts with 2 molecules of G3PB1[3].
