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Contents 1 Assignment 12: IVC: Ammonium Binding Site 2 Script Exercises 3 Outline 4 References

Assignment 12: IVC: Ammonium Binding Site

Mapping the Ammonium binding site and explaining how it contributes to catalysis.

Chang, Yu-Wei and Kaushal, Pankaj.

University of Maryland, Baltimore County (UMBC).

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Script Exercises

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Outline

Glutamine synthetase catalyzes the ATP dependent condensation of glutamate and ammonia, producing, glutamine, ADP, and an inorganic phosphate group.

Glutamate + ATP + NH3 → Glutamine + ADP + phosphate

References

1. Liaw, S-H, et.al.,Discovery of the ammonium substrate site on glutamine synthetase, a third cation binding site Protein Sci. 1995 4: 2358-2365[1]