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RNA Interference
From Proteopedia
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| guide-strand-containing Argonaute protein silencing complex (3dlh), resolution 3.00Å () | |||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
RNA Interference (RNAi) is a system in living cells that helps control the level of activity of genes. In RNAi, a long double stranded RNA is cleaved into shorter strands. One strand known as the guide strand is complimentary to the mRNA gene product of a gene of interest. This guide strand is incorporated into an RNA-induced silencing complex (RISC) and subsequently binds the mRNA of the gene of interest. After binding, the RNA/RISC complex subsequently silences the mRNA of interest via cleavage of the mRNA strand.
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| viral silencing suppressor bound to a siRNA (1rpu), resolution 2.50Å () | |||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Articles in Proteopedia concerning RNA Interference include:
- Suppression of RNA Silencing by Viruses
- Plant Viral Protein p19 Supression of RNA Silencing
- Tomato aspermy virus protein 2b Suppression of RNA Silencing
- Flock house virus B2 protein Suppression of RNA Silencing
To view automatically seeded indices concerning RNA Interference See:
To view other Proteopedia pages about diseases & drug targets, See: Pharmaceutical Drug Targets
