Captopril

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spinqualitylabelsall models Rosiglitazone, also known as Avandia Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Better Known as: Capoten

• Marketed By: Bristol-Myers Squibb
  
• Major Indication: Hypertension & Congestive Heart Failure
  
• Drug Class: ACE Inhibitor
• Date of FDA Approval (Patent Expiration): 1981 (1996)
  
• 2009 Sales: N/A
• Why You Should Care: It was the first Angiotensin-Converting Enzyme Inhibitor. Was one of the earliest successes of Structure-Based drug design.
• The following is a list of Pharmacokinetic Parameters. See: Pharmaceutical Drugs for more information

Mechanism of Action

Pharmacokinetics

ACE-Inhibitor Pharmacokinetics Comparison at Equivalent Dosages
Parameter	Captopril	Lisinopril	Enalapril	Benazepril
Tmax (hr)
Cmax (ng/ml)
Bioavailability (%)
Protein Binding (%)	96.7
T1/2 (hr)
AUC (ng/ml/hr)
IC50 (nM)
Equivalent Dosage (mg)
Metabolism