Sorafenib

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Pharmacokinetics

VEGFR Inhibitor Pharmacokinetics [1][2][3][4][5]
Parameter Sunitinib (Sutent) Sorafenib (Nexavar)
Tmax (hr) 8 8.3
Cmax (ng/ml) 24.6 460
Bioavailability (%) Variable 29-49
Protein Binding (%) 95 99
T1/2 (hr) 83 29
AUC (ng/ml/hr) 1921 11040
Dosage (mg) 50 50
Metabolism Hepatic (CYP3A4) Hepatic (CYP3A4)

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David Canner, Alexander Berchansky, Joel L. Sussman

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