Enolase multiple sequence alignment
From Proteopedia
Multiple Sequence Alignment (MSA) for enolase, an enzyme in glycolysis.
Key: IDENTICAL(*) SIMILAR(.) different Consensus Percentage is set to 100%.
1 ENO_DROME| Drosophila melanogaster --------mt IkaIkARqIy DSRGNPTVEv DLtt-elglf rAavPSGAST 41
2 ENOA_HUMAN| Homo sapiens ---------s IlkIhAReIf DSRGNPTVEv DLft-skglf rAavPSGAST 40
3 ENO_METJA| Methanococcus janaschii mlynmderfe IkdIvAReVi DSRGNPTVEv EVitkgngyg sAivPSGAST 50
4 ENO_ECOLI| Escherichia coli --------sk IvkIiGReIi DSRGNPTVEa EVhleggfvg mAaaPSGAST 42
5 ENO_BACSU| Bacillus subtilis -------mpy IvdVyAReVl DSRGNPTVEv EVytetgafg rAlvPSGAST 43
6 4ENL Yeast| Saccharomyces cerevisiae ---------a VskVyARsVy DSRGNPTVEv ELtt-ekgvf rSivPSGAST 40
. . .* . ********* .. . ******
1 ENO_DROME| Drosophila melanogaster GvhEALElRD nDKanYhGKS VlkAVghVNd tLgpelIkan ldvvdQasID 91
2 ENOA_HUMAN| Homo sapiens GiyEALElRD nDKtrYmGKG VskAVehINk tIapalVskk lnvteQekID 90
3 ENO_METJA| Methanococcus janaschii GthEALElRD kEK-rFgGKG VlmAVenVNs iIrpeiLg-- ydarmQreID 97
4 ENO_ECOLI| Escherichia coli GsrEALElRD gDKsrFlGKG VtkAVaaVNg pIaqalIg-- kdakdQagID 90
5 ENO_BACSU| Bacillus subtilis GeyEAVElRD gDKdrYlGKG VltAVnnVNe iIapelLg-- fdvteQnaID 91
6 4ENL Yeast| Saccharomyces cerevisiae GvhEALEmRD gDKskWmGKG VlhAVknVNd vIapafVkan idvsdQkaVD 90
* **.* ** .* . **. * ** .* . . * .*
1 ENO_DROME| Drosophila melanogaster nfmIklDGTe NKSKfGANAI LGVSlAvaKA GAakkgvPLY khIAdlagn- 140
2 ENOA_HUMAN| Homo sapiens klmIemDGTe NKSKfGANAI LGVSlAvcKA GAvekgvPLY rhIAdlagn- 139
3 ENO_METJA| Methanococcus janaschii timIelDGTp NKSRlGANAI LAVSlAvaKA AAatakiPLY kyLGgfn--- 144
4 ENO_ECOLI| Escherichia coli kimIdlDGTe NKSKfGANAI LAVSlAnaKA AAaakgmPLY ehIAelngt- 139
5 ENO_BACSU| Bacillus subtilis qllIelDGTe NKGKlGANAI LGVSmAcaRA AAdflqiPLY qyLGgfn--- 138
6 4ENL Yeast| Saccharomyces cerevisiae dflIslDGTa NKSKlGANAI LGVSlAasRA AAaeknvPLY khLAdlsksk 140
* *** **.. ***** *.** * .* .* *** .
1 ENO_DROME| Drosophila melanogaster -keiilPVPa fNVINGGsHA gnkLamQEFM IlPtGAtsft EAmKmGSeVY 189
2 ENOA_HUMAN| Homo sapiens -sevilPVPa fNVINGGsHA gnkLamQEFM IlPvGAanfr EAmRiGAeVY 188
3 ENO_METJA| Methanococcus janaschii --syvmPVPm mNVINGGkHA gndLdlQEFM ImPvGAtsis EAvRmGSeVY 192
4 ENO_ECOLI| Escherichia coli pgkysmPVPm mNIINGGeHA dnnVdiQEFM IqPvGAktvk EAiRmGSeVF 189
5 ENO_BACSU| Bacillus subtilis --sktlPVPm mNIVNGGeHA dnnVdiQEFM ImPvGApnfr EAlRmGAqIF 186
6 4ENL Yeast| Saccharomyces cerevisiae tspyvlPVPf lNVLNGGsHA ggaLalQEFM IaPtGAktfa EAlRiGSeVY 190
*** *..*** ** . **** * * ** ** . *. ..
1 ENO_DROME| Drosophila melanogaster HhLknVikaK fgldataVGD EGGfAPnIqs nkEALnlIsd AIakAGyt-- 237
2 ENOA_HUMAN| Homo sapiens HnLknVikeK ygkdatnVGD EGGfAPnIle nkEGLelLkt AIgkAGyt-- 236
3 ENO_METJA| Methanococcus janaschii HvLknVileK ygknavnVGD EGGfAPpLkt srEALdlLte SVkkAGye-- 240
4 ENO_ECOLI| Escherichia coli HhLakVlkaK g--mntaVGD EGGyAPnLgs naEALavIae AVkaAGyelg 237
5 ENO_BACSU| Bacillus subtilis HsLksVlsaK g--lntaVGD EGGfAPnLgs neEALqtIve AIekAGfkpg 234
6 4ENL Yeast| Saccharomyces cerevisiae HnLksLtkkR ygasagnVGD EGGvAPnIqt aeEALdlIvd AIkaAGhd—238
* * . . *** *** ** . *.* . .. **
~~~~~~~~~~~~~~~~~~~~~
1 ENO_DROME| Drosophila melanogaster gkIeiGmDvA ASEFYk--dG qYdLdfknek sdksqwlpad klanlykefi 285
2 ENOA_HUMAN| Homo sapiens dkVviGmDvA ASEFFr--sG kYdLdfksp- ddpsryispd qladlyksfi 283
3 ENO_METJA| Methanococcus janaschii deVvfAlDaA ASEFYk--dG yYyVegkk-- ------ltre elldyykalv 280
4 ENO_ECOLI| Escherichia coli kdItlAmDcA ASEFYk--dG kYvLagegn- ----kaftse efthfleelt 280
5 ENO_BACSU| Bacillus subtilis eeVklAmDaA SSEFYnkedG kYhLsgeg-- ----vvktsa emvdwyeelv 278
6 4ENL Yeast| Saccharomyces cerevisiae gkVkiGlDcA SSEFFk--dG kYdLdfknpn sdkskwltgp qladlyhslm 286
. . * * .***. * * .
~~~~~~~~~~~~~~~~~~~~~
1 ENO_DROME| Drosophila melanogaster kdFPIVSIED pfdqdhWeAw snltgctd-- IQIVGDDLtV TNpkrIatAV 333
2 ENOA_HUMAN| Homo sapiens kdYPVVSIED pfdqddWgAw qkftasag-- IQVVGDDLtV TNpkrIakAV 331
3 ENO_METJA| Methanococcus janaschii deYPIVSIED pfheedFeGf amitkeld-- IQIVGDDLfV TNverLrkGI 328
4 ENO_ECOLI| Escherichia coli kqYPIVSIED gldesdWdGf ayqtkvlgdk IQLVGDDLfV TNtkiLkeGI 330
5 ENO_BACSU| Bacillus subtilis skYPIISIED gldendWeGh kllterlgkk VQLVGDDLfV TNtkkLseGI 328
6 4ENL Yeast| Saccharomyces cerevisiae krYPIVSIED pfaeddWeAw shffktag-- IQIVADDLtV TNpkrIatAI 334
.*..**** . . .*.*.*** * ** . ..
1 ENO_DROME| Drosophila melanogaster ekkacncLLL KvNQIGtVtE siaAhllAkk nGWgtmVSHR SGETEDsfIG 383
2 ENOA_HUMAN| Homo sapiens nekscncLLL KvNQIGsVtE slqAcklAqa nGWgvmVSHR SGETEDtfIA 381
3 ENO_METJA| Methanococcus janaschii emkaanaLLL KvNQIGtLsE avdAaqlAfr nGYgvvVSHR SGETEDttIA 378
4 ENO_ECOLI| Escherichia coli ekgiansILI KfNQIGsLtE tlaAikmAkd aGYtavISHR SGETEDatIA 380
5 ENO_BACSU| Bacillus subtilis kngvgnsILI KvNQIGtLtE tfdAiemAkr aGYtavISHR SGETEDstIA 378
6 4ENL Yeast| Saccharomyces cerevisiae ekkaadaLLL KvNQIGtLsE sikAaqdSfa aGWgvmVSHR SGETEDtfIA 384
.*. . **** . * * . *. .*** ****** *.
1 ENO_DROME| Drosophila melanogaster DLvVGlstGQ IKTGApcRsE RlAKyNQILR IEeeIGagvk FaGksfgkpq 433
2 ENOA_HUMAN| Homo sapiens DLvVGlctGQ IKTGApcRsE RlAKyNQLLR IEeeLGskak FaGrnfrnpl 431
3 ENO_METJA| Methanococcus janaschii DLsVAlnsGQ IKTGApaRgE RtAKyNQLIR IEqeLG-lsk YaGrnfrcpf 427
4 ENO_ECOLI| Escherichia coli DLaVGtaaGQ IKTGSmsRsD RvAKyNQLIR IEeaLGekap YnGrkeikgq 430
5 ENO_BACSU| Bacillus subtilis DIaVAtnaGQ IKTGApsRtD RvAKyNQLLR IEdqLAetaq YhGinsfynl 428
6 4ENL Yeast| Saccharomyces cerevisiae DLvVGlrtGQ IKTGApaRsE RlAKlNQLLR IEeeLGdnav FaGenfhhgd 434
*. *. ** ****. * . * ** **..* ** .. . *
1 ENO_DROME| Drosophila melanogaster -- 433
2 ENOA_HUMAN| Homo sapiens ak 433
3 ENO_METJA| Methanococcus janaschii -- 427
4 ENO_ECOLI| Escherichia coli a- 431
5 ENO_BACSU| Bacillus subtilis nk 430
6 4ENL Yeast| Saccharomyces cerevisiae kl 436
Summary of categories applied to a total of 436 residues in the PDB file sequence for a consensus level setting of 100%: 33% (142) IDENTICAL(*) 16% (68) SIMILAR(.) 52% (226) different Definitions of SIMILAR groups of amino acids: ILV Ile Leu Val hydrophobic, aliphatic / medium-sized side-chain FWY Phe Trp Tyr hydrophobic, aromatic / large side-chain (Tyr polar) KRH Lys Arg His + charge DE Asp Glu - charge GAS Gly Ala Ser small P Pro helix breaking C Cys disulfide-forming TNQM Thr Asn Gln Met polar (except Met)
