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Enolase multiple sequence alignment

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Revision as of 23:31, 30 September 2012 by Eric Martz (Talk | contribs)
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Multiple Sequence Alignment (MSA) for enolase, an enzyme in glycolysis.

Key: IDENTICAL(*) SIMILAR(.) different Consensus Percentage is set to 100%.


 1    ENO_DROME| Drosophila melanogaster  GvhEALElRD nDKanYhGKS VlkAVghVNd tLgpelIkan ldvvdQasID 91
 2              ENOA_HUMAN| Homo sapiens  GiyEALElRD nDKtrYmGKG VskAVehINk tIapalVskk lnvteQekID 90
 3    ENO_METJA| Methanococcus janaschii  GthEALElRD kEK-rFgGKG VlmAVenVNs iIrpeiLg-- ydarmQreID 97
 4           ENO_ECOLI| Escherichia coli  GsrEALElRD gDKsrFlGKG VtkAVaaVNg pIaqalIg-- kdakdQagID 90
 5          ENO_BACSU| Bacillus subtilis  GeyEAVElRD gDKdrYlGKG VltAVnnVNe iIapelLg-- fdvteQnaID 91
 6  4ENL Yeast| Saccharomyces cerevisiae  GvhEALEmRD gDKskWmGKG VlhAVknVNd vIapafVkan idvsdQkaVD 90<o:p></o:p></span></p>

                                          *  **.* **  .*  . **. *  **  .*   .    .         *  .*

 1    ENO_DROME| Drosophila melanogaster  nfmIklDGTe NKSKfGANAI LGVSlAvaKA GAakkgvPLY khIAdlagn- 140
 2              ENOA_HUMAN| Homo sapiens  klmIemDGTe NKSKfGANAI LGVSlAvcKA GAvekgvPLY rhIAdlagn- 139
 3    ENO_METJA| Methanococcus janaschii  timIelDGTp NKSRlGANAI LAVSlAvaKA AAatakiPLY kyLGgfn--- 144
 4           ENO_ECOLI| Escherichia coli  kimIdlDGTe NKSKfGANAI LAVSlAnaKA AAaakgmPLY ehIAelngt- 139
 5          ENO_BACSU| Bacillus subtilis  qllIelDGTe NKGKlGANAI LGVSmAcaRA AAdflqiPLY qyLGgfn--- 138
 6  4ENL Yeast| Saccharomyces cerevisiae  dflIslDGTa NKSKlGANAI LGVSlAasRA AAaeknvPLY khLAdlsksk 140<o:p></o:p>

                                             *  ***  **.. ***** *.** *  .* .*     ***    .

 1    ENO_DROME| Drosophila melanogaster  -keiilPVPa fNVINGGsHA gnkLamQEFM IlPtGAtsft EAmKmGSeVY 189
 2              ENOA_HUMAN| Homo sapiens  -sevilPVPa fNVINGGsHA gnkLamQEFM IlPvGAanfr EAmRiGAeVY 188
 3    ENO_METJA| Methanococcus janaschii  --syvmPVPm mNVINGGkHA gndLdlQEFM ImPvGAtsis EAvRmGSeVY 192
 4           ENO_ECOLI| Escherichia coli  pgkysmPVPm mNIINGGeHA dnnVdiQEFM IqPvGAktvk EAiRmGSeVF 189
 5          ENO_BACSU| Bacillus subtilis  --sktlPVPm mNIVNGGeHA dnnVdiQEFM ImPvGApnfr EAlRmGAqIF 186
 6  4ENL Yeast| Saccharomyces cerevisiae  tspyvlPVPf lNVLNGGsHA ggaLalQEFM IaPtGAktfa EAlRiGSeVY 190<o:p></o:p>

                                                ***   *..*** **    .  **** * * **     ** . *. ..<o:p></o:p>

 1    ENO_DROME| Drosophila melanogaster  HhLknVikaK fgldataVGD EGGfAPnIqs nkEALnlIsd AIakAGyt-- 237
 2              ENOA_HUMAN| Homo sapiens  HnLknVikeK ygkdatnVGD EGGfAPnIle nkEGLelLkt AIgkAGyt-- 236
 3    ENO_METJA| Methanococcus janaschii  HvLknVileK ygknavnVGD EGGfAPpLkt srEALdlLte SVkkAGye-- 240
 4           ENO_ECOLI| Escherichia coli  HhLakVlkaK g--mntaVGD EGGyAPnLgs naEALavIae AVkaAGyelg 237
 5          ENO_BACSU| Bacillus subtilis  HsLksVlsaK g--lntaVGD EGGfAPnLgs neEALqtIve AIekAGfkpg 234
 6  4ENL Yeast| Saccharomyces cerevisiae  HnLksLtkkR ygasagnVGD EGGvAPnIqt aeEALdlIvd AIkaAGhd—238<o:p></o:p>

<![if !vml]><img width=155 height=106 src="msa3d_4enl_msa_files/image001.gif" v:shapes="_x0000_s1027"><![endif]>                                          *

  •   .   .        *** *** ** .     *.*  .   ..  **
                                          01:31, 1 October 2012 (IST)01:31, 1 October 2012 (IST)01:31, 1 October 2012 (IST)01:31, 1 October 2012 (IST)~
 1    ENO_DROME| Drosophila melanogaster  gkIeiGmDvA ASEFYk--dG qYdLdfknek sdksqwlpad klanlykefi 285
 2              ENOA_HUMAN| Homo sapiens  dkVviGmDvA ASEFFr--sG kYdLdfksp- ddpsryispd qladlyksfi 283
 3    ENO_METJA| Methanococcus janaschii  deVvfAlDaA ASEFYk--dG yYyVegkk-- ------ltre elldyykalv 280
 4           ENO_ECOLI| Escherichia coli  kdItlAmDcA ASEFYk--dG kYvLagegn-
kaftse efthfleelt 280

 5          ENO_BACSU| Bacillus subtilis  eeVklAmDaA SSEFYnkedG kYhLsgeg--

vvktsa emvdwyeelv 278

 6  4ENL Yeast| Saccharomyces cerevisiae  gkVkiGlDcA

SSEFFk--dG kYdLdfknpn sdkskwltgp qladlyhslm 286<o:p></o:p>

                                            .  . * * .***.    *  * .                 
                                          01:31, 1 October 2012 (IST)01:31, 1 October 2012 (IST)01:31, 1 October 2012 (IST)01:31, 1 October 2012 (IST)~
 1    ENO_DROME| Drosophila melanogaster  kdFPIVSIED pfdqdhWeAw snltgctd-- IQIVGDDLtV TNpkrIatAV 333
 2              ENOA_HUMAN| Homo sapiens  kdYPVVSIED pfdqddWgAw qkftasag-- IQVVGDDLtV TNpkrIakAV 331
 3    ENO_METJA| Methanococcus janaschii  deYPIVSIED pfheedFeGf amitkeld-- IQIVGDDLfV TNverLrkGI 328
 4           ENO_ECOLI| Escherichia coli  kqYPIVSIED gldesdWdGf ayqtkvlgdk IQLVGDDLfV TNtkiLkeGI 330
 5          ENO_BACSU| Bacillus subtilis  skYPIISIED gldendWeGh kllterlgkk VQLVGDDLfV TNtkkLseGI 328
 6  4ENL Yeast| Saccharomyces cerevisiae  krYPIVSIED pfaeddWeAw shffktag-- IQIVADDLtV TNpkrIatAI 334 Summary of categories applied to a total of 436 residues in the PDB file sequence for a consensus level setting of 100%: 33% (142) IDENTICAL(*) 16% (68) SIMILAR(.) 52% (226) different Definitions of SIMILAR groups of amino acids: ILV Ile Leu Val hydrophobic, aliphatic / medium-sized side-chain FWY Phe Trp Tyr hydrophobic, aromatic / large side-chain (Tyr polar) KRH Lys Arg His + charge DE Asp Glu - charge GAS Gly Ala Ser small P Pro helix breaking C Cys disulfide-forming TNQM Thr Asn Gln Met polar (except Met)

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Eric Martz

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