Dipeptidyl peptidase

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Image:1jqp.png
Crystal Structure of Dipeptidyl peptidase (1jqp)

Template:STRUCTURE 1jqp











Dipeptidyl peptidase (DPP) is an enzyme which cleaves dipeptides from plolypeptides. DPP-IV (or CD26) cleaves proline dipeptides from the N-termini and is associated with immune regulation. DPP-III acts similarly to DPP-IV. DPP-I is involved in inflammatory diseases. DPP-II is a serine protease. The images at the left and at the right correspond to one representative DPP, i.e. the crystal structure of Dipeptidyl peptidase-I from rat (1jqp). See also Dipeptidyl Peptidase-4 Inhibitor Pharmacokinetics.

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3D Structures of Dipeptidyl peptidase

Updated on 20-August-2013

DPP-I

1jqp – rDPP-I – rat
3pdf – hDPP-I + inhibitor - human

DPP-II

3n0t – hDPP-II peptidase domain residues 28-492+inhibitor
3jyh, 4ebb – hDPP-II peptidase domain residues 28-492

DPP-III

3fvy – hDPP-III
3t6b, 3t6j - hDPP-III (mutant) + tynorphin
3csk – DPP-III (mutant) – yeast

DPP-IV

2onc, 1tk3, 1r9m, 1j2e, 1nu6, 1pfq – hDPP-IV extracellular domain
1u8e – hDPP-IV extracellular domain (mutant)
3kwj, 3oc0, 3kwf, 3q8w – hDPP-IV extracellular domain +quinoline derivative
3g0b, 3g0d, 3g0g, 3nox, 3hab, 3hac, 3f8s, 3h0c, 3ccb, 3ccc, 2qjr, 2qky, 3d4l, 2jid, 3bjm, 2rip, 2ole, 2rgu, 2i78, 2oag, 2oqv, 2oqi, 2ogz, 2i03, 2g5p, 2g5t, 2g63, 2bub, 2ajl, 1wcy, 1rwq, 1tkr, 1n1m, 3eio, 3g0c, 3opm, 3sww, 3sx4, 3q0t, 4a5s, 3vjk, 3vjl, 3vjm, 3w2t, 4dsa, 4dsz, 4dtc, 4g1f,3o95, 3o9v – hDPP-IV extracellular domain+inhibitor
1r9n, 2bgr, 1nu8 – hDPP-IV extracellular domain+polypeptide
1w1i – hDPP-IV extracellular domain+adenosine deaminase
2bgn – hDPP-IV extracellular domain+adenosine deaminase+polypeptide
3c43, 3c45, 2qoe, 2qt9, 2qtb, 2p8s, 2oph, 2fjp, 1x70, 2iit, 2iiv, 3qbj – hDPP-IV extracellular domain (mutant) + inhibitor
4kr0 - hDPP-IV extracellular domain + S protein
2gbc – rDPP-IV extracellular domain
2oae, 2i3z, 2gbf, 2gbg, 2gbi – rDPP-IV extracellular domain+inhibitor
2aj8, 2ajb, 2ajc, 2ajd, 2bua, 2buc, 1orw – pDPP-IV extracellular domain+inhibitor - pig
1orv - pDPP-IV extracellular domain
2ecf - DPP-IV – Stenotrophomonas maltophilia

DPP-VI

3pvq – DPP-VI – Bacterioides thetaiotamicron

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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