This is the overall . The membrane access channel is accessible to lipids partitioned in the inner layer of the lipid bilayer. This is the . This is the .
The of FAAH reveals two openings (, ) directly accessible by the inner layer of the lipid bilayer.[1] These (MAC) are made up of three flaps and two intrusions. envelope the middle and backside of the anandamide mimic, and are locked together by a salt bridge between Arg486 and Asp403. each proceed by a respective membrane binding cap. This sturdy flap appears to be loosened by the presence of five positively charged residues, and each MAC remains conformation-stable by a salt bridge. The membrane access channel leads to the active site, which is flanked by both the (ABP and CP).[2] The cytosolic port is a lengthy, flexible loop that leads directly into the cytoplasm, allowing the deacylated amine to enter the cell.
