This is the overall . The membrane access channel is accessible to lipids partitioned in the inner layer of the lipid bilayer. This is the . This is the .
The of FAAH reveals two equivalent openings (, ) directly accessible by the inner layer of the lipid bilayer.[1] These (MAC) are made up of three flaps and two intrusions the which collectively allow the entry and aliphatic binding of the amide lipid substrate. Flaps 1 and 2 envelope the middle and backside of the anandamide mimic, and are locked together by a between Arg486 and Asp403. Flap 2 contains a very hydrophobic membrane binding cap. This binding cap clings to the cell's inner membrane and lures out partitioned anandamide by attracting the substrate's narrow partially negatively charged head group with a multitude of positively charged residues. its each proceed by a respective membrane binding cap. This sturdy flap appears to be loosened by the presence of five positively charged residues, and each MAC remains conformation-stable by a salt bridge. The membrane access channel leads to the active site, which is flanked by both the (ABP and CP).[2] The cytosolic port is a lengthy, flexible loop that leads directly into the cytoplasm, allowing the deacylated amine to enter the cell.
