2anq

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Template:STRUCTURE 2anq

Contents 1 Crystal Structure of E.coli DHFR in complex with NADPH and the inhibitor compound 10a. 2 Function 3 About this Structure 4 See Also 5 Reference

Crystal Structure of E.coli DHFR in complex with NADPH and the inhibitor compound 10a.

Template:ABSTRACT PUBMED 17125251

Function

[DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

About this Structure

2anq is a 1 chain structure with sequence from "bacillus_coli"_migula_1895 "bacillus coli" migula 1895. Full crystallographic information is available from OCA.

See Also

• Dihydrofolate reductase

Reference

• Summerfield RL, Daigle DM, Mayer S, Mallik D, Hughes DW, Jackson SG, Sulek M, Organ MG, Brown ED, Junop MS. A 2.13 A structure of E. coli dihydrofolate reductase bound to a novel competitive inhibitor reveals a new binding surface involving the M20 loop region. J Med Chem. 2006 Nov 30;49(24):6977-86. PMID:17125251 doi:10.1021/jm060570v