Rhomboid protease is a transmembranal serine protease. The active site is buried in the lipid bilayer of cell membrane. It cleaves proteins within their transmembrane domain. Rhomboids regulate many cellular processes and are involved in many human diseases. The catalytic site of rhomboids contains a hydrophilic pocket protected by from the lipid bilayer. Rhomboids are specific for a single transmembranal helix proteins.
3D Structures of rhomboid protease
Updated on 20-April-2014
GlpG
2ic8, 2irv, 2nrf, 2o7l, 3b45, 2xov, 4njn, 4njp – EcGlpG core region – Escherichia coli
2xtu, 3b44, 2xtv – EcGlpG core region (mutant)
4hdd – EcGlpG N terminal
2lep – EcGlpG N terminal - NMR
2nr9, 3odj – HiGlpG - Haemophilus influenzae
2nr9 – HiGlpG (mutant) + detergent
2gqc – RP N terminal – NMR – Pseudomonas aeruginosa
GlgG complex with inhibitor
2xow, 3zeb – EcGlpG core region + isocoumarin inhibitor
3txt, 4h1d – EcGlpG core region + DFP inhibitor
3ubb – EcGlpG core region + phosphonofluoridate inhibitor
3zmh, 3zmi, [[3zmhj], 3zot, 3zmj – EcGlpG core region + β-lactam inhibitor
