Virus protease

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Virus proteases include HIV protease, XMRV protease, retropepsin. HIV Protease (HIV-PR) and xenotropic murine leukemia virus protease (XMRV-PR) cleave polyproteins to produce the mature proteins of the virus. Both are aspartyl proteases. The inhibition of HIV-PR results in an uninfectious HIV virion. HIV-1 is found globally while HIV-2, which has lower virulence, is found in West Africa. See also

1 3D Structures of Virus proteases

3D Structures of Virus proteases

Updated on 28-September-2014

HIV-1

3ixo - HIV1-PR subtype A
1odx, 2hb2, 2hb4, 2pc0, 3bva, 3mws, 3kt2, 3kt5, 4ej8, 4ejl - HIV1-PR (mutant)
1rpi, 1rq9, 1tw7, 3oq7, 3oqa, 3oqd, 3pj6, 3uf3, 3o99, 3o9a, 3o9b, 3o9c, 3o9d, 3o9e, 3o9f, 3o9g, 3o9h, 3o9i, 3u71 -HIV1-PR (drug-resistant mutant)
1odw, 3kf1, 3hvp, 3phv - HIV1-PR
3fsm, 3hlo - HIV1-PR covalent dimer

HIV-1 complexes

1hsg, 1hsh, 1hsi, 3oxc, 3ekv, 3ekx, 3eky, 3el1, 1ohr, 3ndt, 3nls, 3qoz, 3ndu, 3ndw, 3ndx, 3qoz, 3r0w, 3r0y, 4dqb, 4jec, 4hla - HIV1-PR + antiviral drug
4eyr, 4j54, 4j55, 4j5j - HIV1-PR (mutant) + antiviral drug
1aid, 1qbr, 1qbs, 1qbt, 1qbu, 3mxe, 3m9f , 3kf0, 3kf1, 3kfn, 3kfp, 3kfr, 3kfs, 2wkz, 2wl0, 3gga, 3ggv, 3ggx, 2uxz, 2uy0, 1zp8, 1xl2, 1xl5, 1zpa, 1yt9, 2a4f, 1upj, 2upj, 7upj, 1hxb, 1hih, 1hvr, 1hef, 1heg, 4phv, 1w5w, 1w5x, 1w5v, 1w5y, 1t7k, 1npa, 1npv, 1npw, 1eby, 1ec0, 1g2k, 1c6x, 1c6y, 1c6z, 1hwr, 2bpv, 2bpw, 2bpx, 2bpy, 2bpz, 1ody, 1hvh, 3tlh, 1hxw, 3bvb, 3ckt, 3mxd, 3hau, 3haw, 3hbo, 3hdk, 3i2l, 3ia9, 3r4b, 3bgb, 3bgc, 3bhe, 3gi4, 3gi5, 3gi6, 3nwq, 3nwx, 3nyg, 3psu, 3t11, 4fe6, 4a4q, 4i8w, 4i8z - HIV1-PR + inhibitor
2zye - HIV1-PR + inhibitor - neutron
3aid, 1ytg, 1yth, 2nxd, 2nxl, 2nxm, 2fns, 2fnt, 1zj7, 1zlf, 1zpk, 1zsf, 1zsr, 1cpi, 1m0b, 1iiq, 1fqx, 1a30 - HIV1-PR + polypeptide derivative
3gi0 - HIV1-PR covalent dimer + polypeptide
3hzc, 3iaw, 3ka2, 3nxn - HIV1-PR covalent dimer + inhibitor
1sp5 - HIV1-PR + autoproteolytic peptide
4ep2, 4epj, 4eq0, 4eqj - HIV1-PR + substrate
4ejd, 4ejk- HIV1-PR + pepstatin
4f73- HIV1-PR + CA-P2
4f74- HIV1-PR + MA-CA
4f75- HIV1-PR + RH-IN
4f76- HIV1-PR + P1-P6

HIV-1 (mutant) complexes

3nu3, 3nu4, 3nu5, 3nu6, 3nu9, 3nuj, 3nuo, 2qhc, 2qak, 2pym, 2pyn, 2q63, 2q64, 2fxd, 2fxe, 2fgu, 2fgv, 1sdt, 1sdu, 1sdv, 1d4y, 1d4s, 3cyw, 3cyx, 3d1x, 3d1y, 3d1z, 3d20, 3djk, 3dk1, 3n3i, 3oxv, 3oxw, 3oxx, 3oy4, 3k4v, 3lzs, 3lzu, 3lzv, 3so9, 3spk, 3ufn, 4dqh, 3s43, 3s53, 3s54, 3s56, 4dqc, 4dqe, 4dqf, 4dqg - HIV1-PR (mutant) + antiviral drug
2aid, 1hpo, 1tcx, 1gnm, 1gnn, 1gno, 1kzk, 3ok9, 3i8w, 3i7e, 3bxr, 3bxs, 2hc0, 2psu, 2psv, 2fle, 2f3k, 2ien, 2fdd, 2fde, 1t7i, 1t3r, 1mrw, 1mrx, 1msm, 1msn, 1bv9, 3h5b, 3kdb, 3kdc, 3kdd, 3a2o, 3bc4, 3fx5, 3i6o, 3st5, 3qaa, 3qbf, 3qih, 3qn8, 3qp0, 3qpj, 3qrm, 3qro, 3qrs, 4dfg - HIV1-PR (mutant) + inhibitor
2p3b - HIV1-PR subtype B (mutant) + inhibitor
2p3c - HIV1-PR subtype F (mutant) + inhibitor
1zbg, 1z8c, 2az9, 2azc, 2a1e, 1lzq, 1d4k, 1d4l, 1a8k, 1a94, 1axa, 3dox, 3d3t, 4fl8 - HIV1-PR (mutant) + polypeptide derivative
1ztz - HIV1-PR (mutant) + autoproteolytic polypeptide + metalacarborane
3b7v, 3b80, 3mim - HIV1-PR (mutant) + autoproteolytic polypeptide + tetrahedral intermediate
3nxe - HIV1-PR covalent dimer (mutant) + inhibitor
4flg, 4fm6 - HIV1-PR (mutant) + reaction intermediate

HIV-1 (drug-resistant mutant) complexes

3el4, 3el9, 3em3, 3em4, 3em6, 3ggt, 3ggu, 1t7j, 1rv7, 1n49, 1fb7, 3ekp, 3ekq, 3ekt, 3ekw, 3el0, 3el5, 3pwm, 3pwr, 3ucb, 3uhl, 3ttp - HIV1-PR (drug-resistant mutant) + antiviral drug
3ots, 3oty, 3ou1, 3ou3, 3ou4, 3oua, 3oub, 3ouc, 3oud - HIV1-PR (drug-resistant mutant) + peptide
1izh, 1izi, 1fb7, 3t3c, 4fae, 4faf, 3sa3, 3sa4, 3sa5, 3sa6, 3sa7, 3sa8, 3sa9, 3saa, 3sab, 3sac, 3vf5, 3vf7, 3vfa, 3vfb - HIV1-PR (drug-resistant mutant) + inhibitor
2p3a - HIV1-PR subtype B (drug-resistant mutant) + inhibitor
2p3d - HIV1-PR subtype F (drug-resistant mutant) + inhibitor

HIV-2

1jld - HIV2-PR
1hii - HIV2-PR + inhibitor
5upj, 6upj, 3upj, 4upj - HIV2-PR (mutant) + inhibitor
1ida, 1idb, 2mip - HIV2-PR + polypeptide derivative

Feline Immunodeficiency Virus-PR

2hah, 4fiv - FIV-PR residues 39-154 (mutant) + inhibitor
3ogp, 3ogq - FIV-PR residues 39-154 (mutant) + drug
5fiv, 6fiv, 1b11 - FIV-PR + inhibitor
2fiv, 3fiv - SIV-PR (mutant) + substrate

Simian Immunodeficiency Virus-PR

2sam - SIV-PR + inhibitor
1az5 - SIV-PR (mutant)

XMRV-PR

3nr6 – XMRV-PR P14
3p1g – XMRV-PR RNase H domain (mutant)

Rous sarcoma virus protease

1bai – RSVP + polypeptide inhibitor _ Rous sarcoma virus

Human Cytomegalovirus protease

1cmv, 1lay – CMVP (mutant) – human herpes virus 5
1wpo – CMVP
2wpo - CMVP (mutant) + inhibitor

Varicella-Zoster virus protease

1vzv - VZVP (mutant) – human herpes virus

Equine infectious anemia virus protease

2fmb – EIAVP (mutant) + inhibitor

Hepatitis A virus protease

2h9h – HAVP residues 1520-1731 (mutant) + polypeptide inhibitor

Orf 17

3njq – hOrf 17 - human herpes virus 8

Dengue virus protease

3u1i – DvNs2b + peptide – Dengue virus
3u1j – DvNs2b + BPTI
2fom - DvNs2b + DvNs3
2whx – DvNs3 residues 1475-2092

Herpes simplex virus protease

1at3 – HSV II – human herpesvirus 2

Foot-and-Mouth Disease virus protease

2bhg – FMDV – Foot-and-mouth disease virus

Infectious Bronchitis virus protease

2q6d – IBV – infectious bronchitis virus
2q6f – IBV + inhibitor

Yellowtail ascites virus protease

4izj, 4izk – YAV Vp4 (mutant) – yellowtail ascites virus

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

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