3dat

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Template:STRUCTURE 3dat

Contents

Crystal structure of the ternary MTX NADPH complex of Bacillus anthracis dihydrofolate reductase

Template:ABSTRACT PUBMED 19374017

Function

[Q81R22_BACAN] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194]

About this Structure

3dat is a 1 chain structure with sequence from Bacillus anthracis (strain sterne). Full crystallographic information is available from OCA.

See Also

Reference

  • Bennett BC, Wan Q, Ahmad MF, Langan P, Dealwis CG. X-ray structure of the ternary MTX.NADPH complex of the anthrax dihydrofolate reductase: a pharmacophore for dual-site inhibitor design. J Struct Biol. 2009 May;166(2):162-71. PMID:19374017

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