3dau

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Template:STRUCTURE 3dau

Contents 1 Crystal structure of the ternary MTX NADPH complex of Escherichia coli dihydrofolate reductase 2 Function 3 About this Structure 4 See Also 5 Reference

Crystal structure of the ternary MTX NADPH complex of Escherichia coli dihydrofolate reductase

Template:ABSTRACT PUBMED 19374017

Function

[DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

About this Structure

3dau is a 1 chain structure with sequence from Ecoli. Full crystallographic information is available from OCA.

See Also

• Dihydrofolate reductase

Reference

• Bennett BC, Wan Q, Ahmad MF, Langan P, Dealwis CG. X-ray structure of the ternary MTX.NADPH complex of the anthrax dihydrofolate reductase: a pharmacophore for dual-site inhibitor design. J Struct Biol. 2009 May;166(2):162-71. PMID:19374017