4h98

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Template:STRUCTURE 4h98

Contents 1 Candida glabrata dihydrofolate reductase complexed with NADPH and 5-{3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]prop-1-yn-1-yl}-6-ethylpyrimidine-2,4-diamine (UCP1018) 2 About this Structure 3 See Also 4 Reference

Candida glabrata dihydrofolate reductase complexed with NADPH and 5-{3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]prop-1-yn-1-yl}-6-ethylpyrimidine-2,4-diamine (UCP1018)

Template:ABSTRACT PUBMED 23375226

About this Structure

4h98 is a 2 chain structure with sequence from Canga. Full crystallographic information is available from OCA.

See Also

• Dihydrofolate reductase

Reference

• Paulsen JL, Viswanathan K, Wright DL, Anderson AC. Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species. Bioorg Med Chem Lett. 2013 Mar 1;23(5):1279-84. doi: 10.1016/j.bmcl.2013.01.008. , Epub 2013 Jan 11. PMID:23375226 doi:http://dx.doi.org/10.1016/j.bmcl.2013.01.008