4mr0

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Template:STRUCTURE 4mr0

Contents

Crystal structure of PfbA, a surface adhesin of Streptococcus pneumoniae

Template:ABSTRACT PUBMED 24321492

Function

[PFBA_STRR6] Acts as a fibronectin-dependent adhesin and invasin. Binds host (in this case human) fibronectin, plasmin, plasminogen, and human serum albumin. Where the bacteria adhere to human cells there is major recruitment of microvilli which seem to fuse to cover the streptococcal chains. Antibodies to this protein reduce bacterial growth in human blood.

About this Structure

4mr0 is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Beulin DS, Yamaguchi M, Kawabata S, Ponnuraj K. Crystal structure of PfbA, a surface adhesin of Streptococcus pneumoniae, provides hints into its interaction with fibronectin. Int J Biol Macromol. 2013 Dec 7;64C:168-173. doi: 10.1016/j.ijbiomac.2013.11.035. PMID:24321492 doi:http://dx.doi.org/10.1016/j.ijbiomac.2013.11.035

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