3td8

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Template:STRUCTURE 3td8

Contents 1 Structural Analysis of Pneumocystis carinii Dihydrofolate Reductase Complex with NADPH and 2,4-diamino-5-methyl-6-[2'-(4-carboxy-1-pentynyl)-5'-methoxybenzyl]pyrido[2,3-d]pyrimidine 2 Function 3 About this Structure 4 See Also 5 Reference

Structural Analysis of Pneumocystis carinii Dihydrofolate Reductase Complex with NADPH and 2,4-diamino-5-methyl-6-[2'-(4-carboxy-1-pentynyl)-5'-methoxybenzyl]pyrido[2,3-d]pyrimidine

Template:ABSTRACT PUBMED 22505410

Function

[DYR_PNECA] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

About this Structure

3td8 is a 1 chain structure with sequence from Pneca. Full crystallographic information is available from OCA.

See Also

• Dihydrofolate reductase

Reference

• Cody V, Pace J, Stewart E. Structural analysis of Pneumocystis cariniidihydrofolate reductase complexed with NADPH and 2,4-diamino-6-[2-(5-carboxypent-1-yn-1-yl)-5-methoxybenzyl]-5-methylpyrido[2,3-d] pyrimidine. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Apr 1;68(Pt 4):418-23., Epub 2012 Mar 28. PMID:22505410 doi:10.1107/S1744309112008688