Amyloid precursor protein

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Human amyloid precursor protein heparin-binding domain 1mwp

Structural annotation:
Resources:	CATH : 1Mwpa00 InterPro : Ipr011178, Ipr008155, Ipr008154, Ipr015849, Ipr002223, Ipr013803 Pfam : PF02177 SCOP : d1mwpa_ UniProt : P05067

Functional annotation:
Cellular component:	extracellular region membrane integral to membrane integral to plasma membrane cell surface coated pit
Biological process:	endocytosis apoptosis cellular copper ion homeostasis cell adhesion Notch signaling pathway neuromuscular process
Molecular function:	heparin binding endopeptidase inhibitor activity zinc ion binding protein binding copper ion binding metal ion binding identical protein binding iron ion binding serine-type endopeptidase inhibitor activity binding

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

Amyloid precursor protein (APP) is thought to regulate transcription. APP is cleaved by β-secretase and the resulting N terminal peptide which is ca. 40 amino acid long is called hAPP β-peptide. The aggregation of the hAPP β-peptide is the cause of Alzheimer’s Disease. For detailed discussion see