Glucagon

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Revision as of 10:43, 6 March 2016 by Michal Harel (Talk | contribs)

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Function

Glucagon (GLC) is a hormone which raises blood glucose level. GLC causes the liver to convert glycogen to glucose. GLC effect is opposite to that of insulin^[1]. See some details in User:Mary Ball/Glucagon.

Relevance

Glucagon is injected in cases of severe glycemia^[2]. Overdose of β blockers is treated with GLC. Epinephrin-resistant low blood pressure cases are treated with GLC. Pancreatic tumors may cause high levels of GLC.

3D Structures of glucagon

Updated on 06-March-2016

2g49 – hGLC preprotein residues 53-81+ insulin-degrading enzyme – human
1kx6, 2m5p, 2m5q – hGLC - NMR
1nau – hGLC (mutant) – NMR
1bh0 - hGLC (mutant)
1gcn - hGLC