Methyl CpG binding protein

Function

Methyl CpG binding proteins are called MBD1 to MBD4 and contain a methyl-CpG binding domain (MBD) which binds to methylated DNA.
• MBD1 is a transcription regulator. It reverts methylated cytosine bases to cytosine.
• MBD2 is part of the MeCP1 complex which contains also NuRD. MBD2 recruits histone deacetylases and DNA methyltransferases. MBD2 functions as a scaffold protein promoting repression.
• MBD3 binds to hydroxymethylated DNA.
• MBD4 has a G:T mipair-specific activity.
• Methyl CpG binding protein 2 (MeCP2) is present in mature nerve cells and is involved in turning off several genes. For more details see Methyl CpG Binding Protein 2.

Disease

Relevance

Structural highlights