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Anopheles arabiensis Insulin Receptor like Protein

spinqualitylabelsall models Anopheles arabiensis InR kinase domain model Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

The Anopheles arabiensis Insulin Receptor's kinase domain was modeled by Brian Pierce for the 'An arab ts lethal project'

This shows the basic structure of the kinase domain with an . The ATP will sit between them just below Beta 1

shows the ATP binding site (purple) and the catalytic loop (green). Here it is as a .

These are found in other RTKs.

G1000S (magenta), A1133G (orange), T1221I (teal)

And as a

This when mutated to isoleucine resulted in ts lethal mutations in the sevenless and EGFR-like genes in D. melanogster