Structural highlights
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The crystal structure of the major endoglucanase from the thermophilic fungus Thermoascus aurantiacus was determined by single isomorphous replacement at 1.12A resolution. The full sequence supports the classification of the protein in a subgroup of glycoside hydrolase family 5 for which no structural data are available yet. The active site shows eight critical residues, strictly conserved within family 5. In addition, aromatic residues that line the substrate-binding cleft and that are possibly involved in substrate-binding are identified. A number of residues seem to be conserved among members of the subtype, including a disulphide bridge between Cys212 and Cys249.
Atomic resolution structure of the major endoglucanase from Thermoascus aurantiacus.,Van Petegem F, Vandenberghe I, Bhat MK, Van Beeumen J Biochem Biophys Res Commun. 2002 Aug 9;296(1):161-6. PMID:12147244[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Van Petegem F, Vandenberghe I, Bhat MK, Van Beeumen J. Atomic resolution structure of the major endoglucanase from Thermoascus aurantiacus. Biochem Biophys Res Commun. 2002 Aug 9;296(1):161-6. PMID:12147244
