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| This Sandbox is Reserved from January through July 31, 2018 for use in the course HLSC322: Principles of Genetics and Genomics taught by Genevieve Houston-Ludlam at the University of Maryland, College Park, USA. This reservation includes Sandbox Reserved 1311 through Sandbox Reserved 1430.
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1bna Structure
Protein p53 is made of 393 amino acids, consisting of seven domains. These domains include proline rich domain, activation domain 2, transcription activation domain, DNA-binding core domain, C-terminal domain, tetramerzatin domain, and a nuclear localization signaling domain.
Function
Protein p53 is a transcription factor that regulates DNA repair, cell arrest, and apoptosis by . It is activated in response to stressors including radiation, oxidation stress, porto-oncogenes, and DNA-damaging agents.
Significance
References
