Sandbox Reserved 1416

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This Sandbox is Reserved from January through July 31, 2018 for use in the course HLSC322: Principles of Genetics and Genomics taught by Genevieve Houston-Ludlam at the University of Maryland, College Park, USA. This reservation includes Sandbox Reserved 1311 through Sandbox Reserved 1430.
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Contents

1aoi

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Organism or Origin

1aoi, or the complex between nucleosome core particle (H3,h4,h2a,h2b) and 146 BP long DNA fragment, was originally found in the African clawed frog (Xenopus laevis).


Protein Structure

The protein 1aoi is made up of 418 amino acids. It is made up of four pairs of polypeptides: , , , and . Alpha helices of all four core histones generate a positive charge, essential to the function of the protein.

Function

The function of this protein is to control transcription by wrapping DNA around the histones which blocks transcription. This is also done to wrap up DNA into the chromosomes.

Significance

This histone complex is used in DNA binding and initiating DNA-templated transcription. It plays a major role in transcription control. The significance of this protein is that it is within a common testing organism, the African Clawed frog.


References

http://science.sciencemag.org/content/293/5532/1074.full

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