Sandbox Reserved 1417

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This Sandbox is Reserved from January through July 31, 2018 for use in the course HLSC322: Principles of Genetics and Genomics taught by Genevieve Houston-Ludlam at the University of Maryland, College Park, USA. This reservation includes Sandbox Reserved 1311 through Sandbox Reserved 1430.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

Contents

Ubiquitin

DNA Structure

Drag the structure with the mouse to rotate

Ubiquitin is a very important protein utilized in the degradation of other proteins. It is a highly conserved protein that has not changed much during the evolution of life, so it and its related proteins are found in plant cells, yeast cells, and our own cells.

Function and Mechanism

Ubiquitin functions as a protein that regulates the degradation of other proteins. It consists of 76 amino acids and is found in almost all cells. UBQ functions in the ubiquitin-proteasome system. In this system, ubiquitin binds to an E1 protein. This E1 protein helps transfer the ubiquitin to an E2 protein. The E2 protein then binds to an E3 protein which binds to the targeted substrate protein. After this, ubiquitin binds onto the substrate via a glysine in the . This process must occur multiple times () before the ubiquitin signals for the to bind to the substrate. The proteasome then binds to the substrate and degrades the protein.

Disease

The malfunction of ubiquitination has been related to several diseases such as Alzheimer's, Parkinson's and Huntington's diseases. Ubiquitin also plays a major part in cancer specifically metastasis.

Relevance

Structural highlights

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

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References

Definition of Ubiquitin. (n.d.). Retrieved February 25, 2018, from https://www.medicinenet.com/script/main/art.asp?articlekey=26110

Goodsell, D. (2004, December). Ubiquitin. Retrieved February 25, 2018, from http://pdb101.rcsb.org/motm/60

The Ubiquitin Proteasome Pathway (UPP). (n.d.). Retrieved February 25, 2018, from http://www.bostonbiochem.com/about/ubiquitin-proteasome-pathway-upp

Varshavsky, A. (2006). The early history of the ubiquitin field. Protein Science : A Publication of the Protein Society, 15(3), 647–654. http://doi.org/10.1110/ps.052012306

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