1acj shows the crystal structure[1] of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine.
Tacrine is a reversible inhibitor of cholinesterase[2]. It was the first FDA approved drug for the treatment of Alzheimer's disease.
Tacrine’s ring is stacked between the of tryptophan 84 and phenylalanine 330 (W84 and F330). [1]
Function
Disease
Relevance
Structural highlights