Structural Highlights
2dub is a 6 chain structure with sequence from [1]. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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Ligands: | |
Related: | 1DUB, 1EY3 |
Gene: | 2dubA, 2dubB, 2dubC, 2dubD,2dubE, 2dubF ([2]) |
Activity: | lyase activity enoyl-CoA hydratase activity catalytic activity, with EC number [3] |
Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Length: 261 amino acids, Specific chains of 2-enoyl-coa hydratase are: a, b, c, d, e, f . 6 chain structure with sequence from Rattus norvegicus. ligand: CO8. The catalytic water is bound between Glu144 and Glu164 in the hydratase.
Function
Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate. The chains homologous to 2DUB: 1DUB, 1EY3.
(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O
Disease
Dysfunctional MFE2 is one of the most common reasons of peroxi- somal disorder in humans
Relevance
References