Structural Highlights
Length: 261 amino acids, Specific chains of 2-enoyl-coa hydratase are: a, b, c, d, e, f . 6 chain structure with sequence from Rattus norvegicus. ligand: CO8. The catalytic water is bound between Glu144 and Glu164 in the hydratase.
Function
Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate. The chains homologous to 2DUB: 1DUB, 1EY3.
(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O
Disease
Dysfunctional MFE2 is one of the most common reasons of peroxi- somal disorder in humans
Relevance
References
http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DUB
http://jenalib.leibniz-fli.de/cgi-bin/3d_mapping.pl?CODE=2dub&MODE=biological1
https://www.uniprot.org/uniprot/P14604#function