Introduction
The RNA dependent RNA polymerase (RdRp) of SARS-CoV-2 (also known as nsp12), which is responsible for a major outbreak of the disease called Coronavirus Disease 2019 (COVID-19), declared pandemic by WHO in 11 march 2020 [1] is an enzyme that catalyzes the synthesis of RNA of the virus SARS-CoV-2 [2](2). This virus belongs to the betacoronavirus genus [3](Zhou et al. 2020) and has a single stranded positive-sense RNA genome. Therefore, RNA dependent RNA polymerase plays a central role in the virus replication and livecycle. It’s also has been considered a good target for antiviral drugs [4]
