| Structural highlights
4apq is a 4 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | Ligands: | , , , |
| Related: | 1bii, 1bqh, 1bz9, 1cd1, 1ddh, 1ffn, 1ffo, 1ffp, 1fg2, 1fo0, 1fzj, 1fzk, 1fzm, 1fzo, 1g6r, 1g7p, 1g7q, 1hoc, 1inq, 1jpf, 1jpg, 1juf, 1k8d, 1kbg, 1kj2, 1kj3, 1kpu, 1kpv, 1l6q, 1ld9, 1ldp, 1leg, 1lek, 1lk2, 1mhc, 1mwa, 1n3n, 1n59, 1n5a, 1nam, 1nan, 1nez, 1osz, 1p1z, 1p4l, 1pqz, 1qo3, 1rjy, 1rjz, 1rk0, 1rk1, 1s7q, 1s7r, 1s7s, 1s7t, 1s7u, 1s7v, 1s7w, 1s7x, 1t0m, 1t0n, 1u58, 1vac, 1vad, 1wbx, 1wby, 1wbz, 1yn6, 1yn7, 1z5l, 1zhb, 1zhn, 1zt1, 1zt7, 2akr, 2ckb, 2clv, 2clz, 2fik, 2fwo, 2mha, 2vaa, 2vab, 2ve6 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[CD1D1_MOUSE] Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.[1] [2] [3] [B2MG_MOUSE] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
See Also
References
- ↑ Jayawardena-Wolf J, Benlagha K, Chiu YH, Mehr R, Bendelac A. CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain. Immunity. 2001 Dec;15(6):897-908. PMID:11754812
- ↑ Zajonc DM, Maricic I, Wu D, Halder R, Roy K, Wong CH, Kumar V, Wilson IA. Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity. J Exp Med. 2005 Dec 5;202(11):1517-26. Epub 2005 Nov 28. PMID:16314439 doi:10.1084/jem.20051625
- ↑ Zajonc DM, Cantu C 3rd, Mattner J, Zhou D, Savage PB, Bendelac A, Wilson IA, Teyton L. Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor. Nat Immunol. 2005 Aug;6(8):810-8. Epub 2005 Jul 10. PMID:16007091 doi:10.1038/ni1224
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