From Proteopedia
proteopedia linkproteopedia link Bromodomain of PfBDP1
In 2023, globally, there were an estimated 263 million new malaria cases and 597,000 deaths. Plasmodium falciparum, the causative parasite of malaria, invade red blood cells and consumes hemoglobin, preventing oxygen transport to the heart, resulting in heart failure. Additionally, parasitized RBCs stick to the wall of blood vessels in the heart and brain to evade the immune system, which leads to inflammation and blood vessel blockage to these vital organs thus, it is imperative to understand the essential factors involved in the P. falciparum RBC invasion process to develop therapeutic interventions. Previous research has shown that the P. falciparum Bromodomain Protein 1 (PfBDP1) plays an important role in red blood cell invasion by binding to acetylated chromatin at the promoters of invasion genes, promoting their expression, and knockdown of PfBPD1 strongly reduces expression, and blocks the invasion of RBCs. This suggests that the chromatin binding activity of PfBDP1 plays an important role in regulating the expression of invasion-related genes. The bromodomain of PfBDP1 harbors , which is a conserved structural element amongst bromodomains.
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Function
Binds acetylated lysines at promoters of genes implicated in host cell invasion
Disease
Relevance
Structural highlights
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References
