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User:Wayne Chang

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Assignment 12: IVC: Ammonium Binding Site

Mapping the Ammonium binding site and explaining how it contributes to catalysis.

Chang, Wayne and Kaushal, Pankaj.

University of Maryland, Baltimore County (UMBC).



Script Exercises

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Outline

Glutamine synthetase catalyzes the condensation of glutamate and ammonia, using ATP, to form glutamine, ADP, and an inorganic phosphate group.

Glutamate + ATP + NH3 → Glutamine + ADP + phosphate

References

1. Liaw, S-H, et.al.,Discovery of the ammonium substrate site on glutamine synthetase, a third cation binding site Protein Sci. 1995 4: 2358-2365[1]

Proteopedia Page Contributors and Editors (what is this?)

Wayne Chang, Eran Hodis

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