Doppel
From Proteopedia
Doppel (Dpl), named for downstream prion protein-like[1], is a homolog of the prion protein (PrP). It is a cell surface glycoprotein.
Structure of Dpl
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| 1lg4, 20 NMR models () | |||||||||
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| Gene: | Prnd (Homo sapiens) | ||||||||
| Related: | 1i17 | ||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Dpl has the same fold as PrP, with three alpha helices and two short beta strands[2]. however it differs in that the third helix has a significant kink in it and it also contains two disulphide bonds.
The structure mutant PrP with the additional disulphide bond was also determoned [3]
