RNA Interference

From Proteopedia

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spinqualitylabelsall models PDB ID 3dlh Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
guide-strand-containing Argonaute protein silencing complex (3dlh), resolution 3.00Å ()
Resources:	FirstGlance, OCA, PDBsum, RCSB
Coordinates:	save as pdb, mmCIF, xml

RNA Interference (RNAi) is a system in living cells that helps control the level of activity of genes. In RNAi, a long double stranded RNA is cleaved into shorter strands. One strand known as the guide strand is complimentary to the mRNA gene product of a gene of interest. This guide strand is incorporated into an RNA-induced silencing complex (RISC) and subsequently binds the mRNA of the gene of interest. After binding, the RNA/RISC complex subsequently silences the mRNA of interest via cleavage of the mRNA strand.

spinqualitylabelsall models PDB ID 1rpu Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
viral silencing suppressor bound to a siRNA (1rpu), resolution 2.50Å ()
Resources:	FirstGlance, OCA, PDBsum, RCSB
Coordinates:	save as pdb, mmCIF, xml

Articles in Proteopedia concerning RNA Interference include:

• Suppression of RNA Silencing by Viruses
• Plant Viral Protein p19 Supression of RNA Silencing
• Tomato aspermy virus protein 2b Suppression of RNA Silencing
• Flock house virus B2 protein Suppression of RNA Silencing

To view automatically seeded indices concerning RNA Interference See:

• Argonaute
• Dicer
• Drosha
• Piwi
• RISC
• RNAi
• RNAi Suppression
• RNA Interference
• Slicer

To view other Proteopedia pages about diseases & drug targets, See: Pharmaceutical Drug Targets