User:Lori Wetmore/Sandbox 2

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Look for a family of channels (ion or otherwise) or transporters.

I'm going to discuss the family of potassium ion channels, and the specific channel I'll be using to illustrate will be the KcsA potassium ion channel. (http://www.rcsb.org/pdb/explore/explore.do?structureId=1k4c) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2383984/ http://www.ks.uiuc.edu/Research/smd_imd/kcsa/ http://jgp.rupress.org/content/128/5/569.long http://www.ncbi.nlm.nih.gov/pubmed/18621821 http://ion.ucdavis.edu/pdfs/bj02-KcsA.pdf http://ion.ucdavis.edu/pdfs/kchan1.pdf http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TFB-4HDGBRG-2&_user=10&_coverDate=03%2F01%2F2006&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=d94a553308aa392e2459e882bb909dae&searchtype=a

Here are just a few of the things that I'll want to incorporate into my page at some point:

When viewed in (where the N-terminus is gradually shaded into the C-terminus according to the scale below)

N               C

The structure of the KcsA K+ channel

Drag the structure with the mouse to rotate

Contents

KcsA: A K+ channel

Potassium, a major cation in most cells, is responsible (in addition to other cations such as sodium) for the creation of the cell membrane potential, which is responsible for the generation of an action potential, which is necessary for a number of cellular functions such as neurotransmission, muscle contraction, and heart function. The proper balance of potassium in the cell is maintained by potassium ion pumps in the cellular membrane. To date, there are five potassium ion channels with a resolved structure (KcsA, KirBac1.1, KirBac3.1, KvAP, MthK), with KirBac3.1 being the most recently resolved, and they are all tetramers with several conserved secondary structural elements.

Channel Structure

Selecvitity Filter/s

Channel Function

Gating Mechanism

Ongoing Research

References

[1]

Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution.Zhou, Y., Morais-Cabral, J.H., Kaufman, A., MacKinnon, R. Journal: (2001) Nature 414: 43-48 PubMed: 11689936 View PubMed Abstract at NCBI DOI: 10.1038/35102009

Proteopedia Page Contributors and Editors (what is this?)

Lori Wetmore

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