Ribosomal protein L5
From Proteopedia
Ribosomal protein L5 (RPL5) is one of the 34 proteins which belong to the large 50S subunit of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It is known to bind to the 5S RRNA from the large subunit. In the archaea like in Haloarcula marismortui, the L5 is called L5P (RPL5P). The images at the left and at the right correspond to one representative RPS20, i.e. the crystal structure of Ribosomal protein L5 from Thermus thermophilus (2xg0, chain G).
3D Structures of Ribosomal protein L5
RPL5
1iq4 – RPL5 – Geobacillus stearothermophilus
L5 in 50S subunit+RNA
2xg0, 2xg2, 3kir, 3kit, 3kiw, 3kiy – TtRPL5 in 50S subunit+RNA fragments - Thermus thermophilus
2x9s, 2x9u, 3kni, 3knk, 3knm, 3kno, 2wrj, 2wrl, 2wro, 2wrr, 3hux, 3huz, 2wh2, 2wh4, 2wdi, 2wdj, 2wdl, 2wdn, 1vsp, 2v47, 2v49, 1vsa, 2hgj, 2hgq, 2hgu, 2j01, 2j03, 1yl3, 3mrz, 3ms1, 3i8f, 3i8i, 3i9c, 3i9e, 3f1f, 3f1h, 3d5b, 3d5d, 2b66, 2b9n, 2b9p, 1giy - TtRPL5 in 50S subunit+5S RRNA+23S RRNA
3fin - TtRPL5 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM
2wwq – EcRPL5 in 50S subunit+5S RRNA+23S RRNA+mRNA+P-site tRNA – Escherichia coli
3i1n, 3i1p, 3i1r, 3i1t, 3i20, 3i22, 3e1b, 3e1d, 3df2, 3df4, 2vhn, 2qov, 2qox, 2i2t, 2i2v, 1vs6, 1vs8, 2aw4, 2awb, 3ofd, 3og0 - EcRPL5 in 50S subunit+5S RRNA+23S RRNA
3fik, 2gya, 2gyc, 3bbx, 1p85, 1p86 - EcRPL5 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM
3kcr - EcRPL5 in 50S subunit+5S RRNA+23S RRNA+preprotein translocase
2rdo - EcRPL5 in 50S subunit+5S RRNA+23S RRNA+EF-G+RRF – Cryo-EM
3bbo - RPL5 in 50S subunit+5S RRNA+23S RRNA+4.8S RRNA – Cryo-EM – spinach
3iy9 – RPL5 in 50S subunit – Leishmania taretolae
2zjq, 2zjr - DrRPL5 in 50S subunit+5S RRNA+23S RRNA – Deinococcus radiodurans
1kqs, 1qvg - HmRPL5P in 50S subunit+5S RRNA+23S RRNA+CCA - Haloarcula marismortui
1jj2, 1ffk, 3cc2, 2qa4, 1s72 - HmRPL5P in 50S subunit+5S RRNA+23S RRNA
3cc7, 3cce, 3ccj, 3ccl, 3ccm, 3ccq, 3ccr, 3ccs, 3ccu, 3ccv - HmRPL5P in 50S subunit+5S RRNA+23S RRNA (mutant)
1vq4, 1vq5, 1vq7, 1vql, 1vqm, 1vqp - HmRPL5P in 50S subunit+5S RRNA+23S RRNA+transition state analog
1vq6, 1vqk, 1vqn - HmRPL5P in 50S subunit+5S RRNA+23S RRNA+ c-hpmn+CCA-Phe-caproic acid-biotin
1vqo - HmRPL5P in 50S subunit+5S RRNA+23S RRNA+ CCPMN
1yhq, 1yi2, 1yij, 1yjn, 1yjw - HmRPL5P in 50S subunit+5S RRNA+23S RRNA (mutant)+antibiotic
1yj9 - HmRPL5P in 50S subunit (L22 mutant)+5S RRNA+23S RRNA
1qvf - HmRPL5P in 50S subunit+5S RRNA+23S RRNA + deacylated tRNA minihelix
1q86 - HmRPL5P in 50S subunit+5S RRNA+23S RRNA+CCA-Phe-caproic acid-biotin
L5 in 50S subunit + antibiotics
3cxc – RPL5 in 50S subunit+5S RRNA+23S RRNA +oxazolidinone inhibitor – Halobacterium marismortui
3dll - DrRPL5 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+oxazolidinone inhibitor
2zjp - DrRPL5 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+nosiheptide
3cf5 - DrRPL5 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+thiostrepton
1xbp - DrRPL5 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+thiamulin
1sm1 - DrRPL5 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+quinupristin+dalfopristin
1nwx - DrRPL5 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+ABT-773
1nwy - DrRPL5 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+azithromycin
3oh5, 3oh7 – TtRPL5 in 50S subunit+5S RRNA+23S RRNA+chloramphenicol
3ohj, 3ohk – TtRPL5 in 50S subunit+5S RRNA+23S RRNA+erythromycin
3ohz, 3oi1 – TtRPL5 in 50S subunit+5S RRNA+23S RRNA+azithromycin
3oi3, 3oi5 – TtRPL5 in 50S subunit+5S RRNA+23S RRNA+telithromycin
2qam, 2qao, 2qoz, 2qp1 - EcRPL5 in 50S subunit+5S RRNA+23S RRNA+neomycin
2qba, 2qbc - EcRPL5 in 50S subunit+5S RRNA+23S RRNA+gentamicin
3ofc – EcRPL5 in 50S subunit+5S RRNA+23S RRNA+chloramphenicol
3ofz – EcRPL5 in 50S subunit+5S RRNA+23S RRNA+clindamycin
3ofq, 3ofr – EcRPL5 in 50S subunit+5S RRNA+23S RRNA+erythromycin
1vt2, 3orb – EcRPL5 in 50S subunit+5S RRNA+23S RRNA+CEM-101
1k73, 1kc8, 1k8a, 1k9m, 1kd1, 1m1k, 3i55, 3i56, 3g4s, 3g6e, 3g71, 2qex, 3cpw, 3cc4, 3cd6, 2otj, 2otl, 1yit, 1q7y, 1q81, 1q82, 1n8r, 1nji - HmRPL5P in 50S subunit+5S RRNA+23S RRNA+antibiotics
1m90, 3cma, 3cme, 1vq8, 1vq9 - HmRPL5P in 50S subunit+5S RRNA+23S RRNA+ sparsomycin+CCA-Phe-caproic acid-biotin
L5 in 60S subunit
3jyw - RPL5 in 60S subunit – Thermomyces lanuginosus – Cryo-EM
1s1i - yRPL5 in 40S ribosomal subunit+18S RRNA+elongation factor 2 – Cryo-EM – yeast
L5 in large + small ribosomal subunit
1ml5 - EcRPL5 in 50S ribosomal subunit+30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+tRNA Phe+mRNA fragment+23S RRNA+5S RRNA+16S RRNA – EM
2zkr - RPL5 in 60S ribosomal subunit+30S ribosomal subunit+28S RRNA+5.8S RRNA – Cryo-EM - dog
L5 in 50S subunit + ribosome releasing factor (RRF)
2qbe, 2qbg, 2qbi, 2qbk, 2z4l, 2z4n - EcRPL5 in 50S subunit+5S RRNA+23S RRNA+RRF
L5 in 50S subunit + various proteins
2vhm - EcRPL5 in 50S subunit+5S RRNA+23S RRNA+PDF C-terminal helix
2j28 - EcRPL5 in 50S subunit+5S RRNA+23S RRNA+signal recognition particle – Cryo-EM
1vor, 1vou, 1vow, 1voy, 1vp0, 1pnu, 1pny - EcRPL5 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc
1nkw - DrRPL5 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc
1w2b - HmRPL5P in 50S subunit+5S RRNA+23S RRNA+trigger factor N-terminal
L5 in part of 50S subunit
3iyx, 3iyy – EcRPL5+RPS13+RPL31 – Cryo-EM
1mji – TtRPL5+5S RRNA
