HIV Protease Inhibitor Resistance Profile

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This page serves as a hub for visualizing the various mutations that confer resistance to Human Immunodeficiency Virus against various. HIV Protease Inhibitors. Listed are various approved treatments and combinations for HIV (See: Treatments) along with those mutations which typically confer resistance to the drug. Modifications to this should be made here[1][2][3]

Ligands, Cofactors and Coenzymes

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Resistance Mutations
Inhibitor/ Mutation Site L10 V11 I13 G16 K20 L24 D30 V32 L33 E34 E35 M36 K43 M46 I47 G48 I50 F53 I54 Q58 D60 I62 L63 I64 H69 A71 G73 T74 L76 V77 V82 N83 I84 I85 N88 L89 L90 I93
Ritonavir I,R,V - - - M,R - - I F - - I - I,L - - - - V,L - - - - - - V,T - - - I A,F,T, S - V - - - M -
Indinavir I,R,V - - - M,R I - I - - - I - I,L - - - - V - - - - - - V,T S,A - - I A,F,T V - - - M -
Saquinavir I,R,V - - - - - - - - - - - - - - V - - V,L - - - - - - V,T S - - I A - V - - - M -
Nelfinavir F,I - - - - - N - - - - I - I,L - - - - - - - - - - - V,T - - - I A,F,T, S - V - D,S M -
Amprenavir F,I,R, V - - - - - - I - - - - - I,L V - V - L,V,M - - - - - - - S - - - - - V - - - M -
Atazanavir I,F,V - - - R,M,I I - I I,F,V - - I,L,V - I - V L - L - - - - - - V C,S,T, A - - - A - V - S - M -
Lopinavir & Ritonavir F,I,R, V - - - M,R I - I F - - - - I,L V,A - V L V,L,A, M,T,S - - - P - - V,T S - V - A,F,T, S - V - - - M
Atazanavir & Ritonavir I,F,V, C - - E R,M,I, T,V I - I I,F,V Q - I,L,V - I,L - V V L,Y L,V,M, T,A - E V - L,M,V - V,I,T, L C,S,T, A - - - A,T,F, I - V V S - M L,M
Darunavir & Ritonavir - I - - - - - I F - - - - - V - V - M,L - - - - - - - - P V - - - V - - V - -
Fosamprenavir & Ritonavir F,I,R, V - - - - - - I - - - - - I,L V - V - L,V,M - - - - - - - S - V - A,F,S, T - V - - - M -
Indinavir & Ritonavir I,R,V - - - M,R I - I - - - I - I,L - - - - V - - - - - - V,T S,A - V I A,F,T - V - - - M -
Saquinavir & Ritonavir I,R,V - - - - I - - - - - - - - - V - - V,L - - V - - - V,T S - - I A,F,T, S - V - - - M -
Tipranavir & Ritonavir V - V - M,R - - - F - G I T L V - - - A,M,V E - - - - K - - P - - L,T D V - - - M -

References

  1. ↑ Poveda E, de Mendoza C, Martin-Carbonero L, Corral A, Briz V, Gonzalez-Lahoz J, Soriano V. Prevalence of darunavir resistance mutations in HIV-1-infected patients failing other protease inhibitors. J Antimicrob Chemother. 2007 Oct;60(4):885-8. Epub 2007 Jul 23. PMID:17646201 doi:10.1093/jac/dkm276
  2. ↑ Johnson VA, Brun-Vezinet F, Clotet B, Gunthard HF, Kuritzkes DR, Pillay D, Schapiro JM, Richman DD. Update of the drug resistance mutations in HIV-1: December 2009. Top HIV Med. 2009 Dec;17(5):138-45. PMID:20068260
  3. ↑ Johnson VA, Brun-Vezinet F, Clotet B, Conway B, D'Aquila RT, Demeter LM, Kuritzkes DR, Pillay D, Schapiro JM, Telenti A, Richman DD. Drug resistance mutations in HIV-1. Top HIV Med. 2003 Nov-Dec;11(6):215-21. PMID:14724329

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