From Proteopedia
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| Glitazone Pharmacokinetics Comparison at Equivalent Dosages [1][2][3][4]
|
| Parameter
| Lapatinib (Tykerb)
| Sunitinib (Sutent)
| Sorafenib (Nexavar)
|
| Tmax (hr)
| Lapatinib (Tykerb)
| Sunitinib (Sutent)
| Sorafenib (Nexavar)
|
| Cmax (ng/ml)
| Lapatinib (Tykerb)
| Sunitinib (Sutent)
| Sorafenib (Nexavar)
|
| Bioavailability (%)
| Lapatinib (Tykerb)
| Sunitinib (Sutent)
| Sorafenib (Nexavar)
|
| Protein Binding (%)
| Lapatinib (Tykerb)
| Sunitinib (Sutent)
| Sorafenib (Nexavar)
|
| T1/2 (hr)
| Lapatinib (Tykerb)
| Sunitinib (Sutent)
| Sorafenib (Nexavar)
|
| AUC (ng/ml/hr)
| Lapatinib (Tykerb)
| Sunitinib (Sutent)
| Sorafenib (Nexavar)
|
| IC50 (nM)
| Lapatinib (Tykerb)
| Sunitinib (Sutent)
| Sorafenib (Nexavar)
|
| Clearance (ml/hr)
| Lapatinib (Tykerb)
| Sunitinib (Sutent)
| Sorafenib (Nexavar)
|
| Equivalent Dosage (mg)
| Lapatinib (Tykerb)
| Sunitinib (Sutent)
| Sorafenib (Nexavar)
|
| Metabolism
| Lapatinib (Tykerb)
| Sunitinib (Sutent)
| Sorafenib (Nexavar)
|
