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Lapatinib
From Proteopedia
Pharmacokinetics
| Tyrosine Kinase Inhibitor Pharmacokinetics [1][2][3][4][5] | |||||
|---|---|---|---|---|---|
| Parameter | Lapatinib (Tykerb) | Sunitinib (Sutent) | Sorafenib (Nexavar) | ||
| Tmax (hr) | 4 | 8 | 8.3 | ||
| Cmax (ng/ml) | 115 | 24.6 | 460 | ||
| Bioavailability (%) | Lapatinib (Tykerb) | Sunitinib (Sutent) | 29-49 | ||
| Protein Binding (%) | 99 | 95 | 99 | ||
| T1/2 (hr) | 9.6 | 83 | 29 | ||
| AUC (ng/ml/hr) | 1429 | 1921 | 11040 | ||
| IC50 (nM) | Lapatinib (Tykerb) | Sunitinib (Sutent) | Sorafenib (Nexavar) | ||
| Dosage (mg) | 100 | 50 | 50 | ||
| Metabolism | Hepatic (CYP3A4) | Hepatic (CYP3A4) | Hepatic (CYP3A4) | ||
