Oseltamivir

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spinqualitylabelsall models Oseltamivir, better known as Tamiflu, ([[____]]) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Better Known as: Tamiflu

• Marketed By:
• Major Indication: Influenza Infection
• Drug Class: Neuraminidase Inhibitor
• Date of FDA Approval:
• 2009 Sales: $3.1 Billion
• Importance:
• See Pharmaceutical Drugs for more information about other drugs and diseases.

Mechanism of Action

H274Y

Pharmacokinetics

Neuraminidase Inhibitor Pharmacokinetics Parameter Zanamivir Oseltamivir Tmax (hr) 1.25 1.5 Cmax (ng/ml) 31.6 57 Bioavailability (%) 2 75 Protein Binding (%) 10 42 T1/2 (hr) 3 3.2 AUC (ng/ml/hr) 185 204 Clearance (L/h) 54.1 18.8 Dosage (mg) 10 300 Metabolism None Hepatic For References to Pharmacokinetic data, see: References

References